Osteopontin and Integrin alpha v beta 3 Expression during the Implantation Window in IVF Patients with Elevated Serum Progesterone and Oestradiol Level

Background: To explore whether endometrial receptivity is determined by osteopontin (OPN) and integrin avp3 expression in women with elevated serum progesterone (P) and/or oestradiol (E2) who are undergoing in vitro fertilisation (IVF). Methods: According to serum hormone levels on the day of I-ICC administration, 33 infertile women were divided into 3 groups: the high E2, high P, and high E2 and P groups. The control group included 11 fertile, healthy women. Endometrial biopsy was performed on ovulation day + 7 to + 8 for all study participants, and the mRNA and protein expression levels of OPN and integrin aV beta 13 were analyzed, Result: No statistically significant differences regarding OPN and integrin avp3 expression were found between infertile patients in the high P. high E2, high E2 and P and control groups. There was no significant correlation between OPN and integrin avp3 staining intensity during the implantation window biopsy in any of the groups studied, ``Conclusion: Endometrial OPN and integrant avp3 expression/co-expression is not impaired during the window of implantation in patients with high P. high E2, or high E2 and P levels. The clinical value of assessing endometrial receptivity with OPN and integrin avp3 seems to be uncertain,SCI(E)PubMedARTICLEroseli001@sina.com; wuzes2010@163.com6709-7177