Putting gold nanocages to work for optical imaging, controlled release and cancer theranostics

Gold nanocages are hollow nanostructures with ultrathin, porous walls. They are bio-inert and their surface can be readily modified with functional groups to specifically interact with the biological system of interest. They have remarkable optical properties, including localized surface plasmon resonance peaks tunable to the near-infrared region, strong absorption and scattering, as well as two-and three-photon luminescence. With the establishment of robust protocols for both synthesis and surface functionalization, Au nanocages have been extensively explored for various biomedical applications. In this review, we begin with a brief account of the synthesis and properties of Au nanocages, and then highlight some of the recent developments in applying them to an array of biomedical applications related to optical imaging, controlled release and cancer theranostics.National Cancer Institute [1R01 CA 138527]; NIH Director's Pioneer Award [DP1 OD000798]; Georgia Institute of Technology; China Scholarship CouncilSCI(E)REVIEWyounan.xia@bme.gatech.edu131715-17281