Impacts of high flux hemodialysis with hemoperfushion on calcium, phosphorus and parathyroid hormone in maintenance hemodialysis patients

目的 研究高通量血液透析(HFD)联合血液灌流(ⅢP)对维持性血液透析患者血清钙磷及甲状旁腺激素代谢的影响.方法 40例维持性血液透析患者随机分为对照组(高通量血液透析)和观察组(高通量血液透析联合血液灌流),在试验前及试验1和3个月后分别检测两组患者透析前肌酐(Cr)、尿素氮(BUN)、磷(P)、钙(Ca)、全段甲状旁腺激素(iPTH)等生化指标并进行比较.结果 高通量血液透析联合血液灌流与单纯高通量透析者间比较,血清BUN、Cr、Ca差异无统计学意义(P＞0.05);但iPTH、P在两种血液净化模式下差异有统计学意义(P＜0.05).结论 HFD+ HP血液净化方式能有效降低维持性血液透析患者P、iPTH水平,进而可能会提高其生存质量.Objective To study the effects of high flux hemodialysis with hemoperfushion on calcium,phosphorus and parathyroid hormone in hemodialysis patients.Methods Forty patients were randomly devived into the control group(HFD) and the experimental group (HFD + HP).Serum Cr,BUN,P,Ca,iPTH were compared between two groups at baseline and 1 and 3 months.Results There were no differences of serum Cr,BUN,Ca between the two groups (P ＞ 0.05).But the differences of serum iPTH and P were significant (P ＜ 0.05).Conclusion The combination of HFD + HP can reduce P and iPTH product,and HFD + HP could be better than HFD.434-361