Analysis of stage and clinical pathological characteristics of invasive lobular carcinoma with the 8th AJCC Cancer Staging system

目的 研究AJCC第8版乳腺癌分期系统对乳腺浸润性小叶癌分期评价的临床意义及其临床病理特征分析.方法 参照AJCC第8版乳腺癌分期标准,重新对2011-2016年北京大学深圳医院乳腺外科治疗的浸润性小叶癌患者进行解剖学分期及预后分期评价,并与其他类型浸润性癌的临床病理资料进行分析.结果 共收治乳腺浸润性小叶癌21例,占全部浸润性乳腺癌的2.7％,研究发现浸润性小叶癌与其他类型浸润性乳腺癌相比,年龄分布、月经状况、分子分型特征及解剖学分期与预后分期差异均无统计学意义(P＞0.05);而组织学分级差异有统计学意义(P＜0.05).浸润性小叶癌解剖学分期与预后分期评价存在差异.结论 AJCC第8版乳腺癌分期系统中的预后分期为乳腺癌的临床治疗方案的制订提供了新的参考依据,但需参考解剖学分期共同评价.浸润性小叶癌与其他类型浸润性癌相比,组织学分级低,预后分期佳,但要对浸润性小叶癌进行精准的个体化治疗还需要更大样本更完善的研究.Objective To study the meaning of breast cancer staging system by AJCC eighth edition to invasive lobular carcinoma and analysis the clinical pathological characteristics.Methods According to the eighth edition of the AJCC staging to evaluate the TNM stage and prognosis evaluation of invasive lobular carcinoma cancer patient in Peking University Shenzhen Hospital from 2011 to 2016,and compared with others in clinical pathological data.Results There were 21 cases of invasive lobular carcinoma,accounting for 2.7％ of all invasive breast cancer.We found that invasive lobular carcinoma shows no significant difference (P ＞ 0.05) in ages,menstrual status,molecular features and anatomic staging and prognosis staging with others;histological grade were significantly different (P ＜ 0.05).There were significant differences in the prognosis and staging of invasive lobular carcinoma.Conclusions Eighth AJCC staging systemn provides a new reference for the clinical treatment of breast cancer,should be evaluated with anatomic stage.Histological grade is relatively good in invasive lobular carcinoma and the prognosis is good,needs more research to the individualized treatment of invasive lobular carcinoma.5328-3314