Prevalence of tardive dyskinesia in chronic male inpatients with schizophrenia on long term clozapine versus typical antipsychotics

This study aimed to examine the prevalence and clinical correlates of tardive dyskinesia(TD) in a large sample of Chinese inpatients with schizophrenia on long-term treatment with clozapine versus typical antipsychotics.Five hundred and eighty-four male inpatients with schizophrenia on long-term clozapine(n=341) or typical antipsychotic(n=243) treatment were evaluated with the abnormal involuntary movement scale(AIMS).The patient s psychopathology was assessed using the Positive and Negative Syndrome Scale(PANSS).The overall TD prevalence was 44.5%,with rates of 48.7%in the clozapine group and 38.7%in the typical antipsychotic group(p=0.017).The AIMS score was significantly lower in typical than in clozapine groups(p<0.005).A multiple regression analysis showed that the following variables were significandy associated with the AIMS score:clozapine vs typical medication(p=0.008),PANSS negative subscore(p=0.017) and age(p=0.04).There are significant differences in the prevalence and clinical correlates of TD in...This study aimed to examine the prevalence and clinical correlates of tardive dyskinesia(TD) in a large sample of Chinese inpatients with schizophrenia on long-term treatment with clozapine versus typical antipsychotics.Five hundred and eighty-four male inpatients with schizophrenia on long-term clozapine(n=341) or typical antipsychotic(n=243) treatment were evaluated with the abnormal involuntary movement scale(AIMS).The patient s psychopathology was assessed using the Positive and Negative Syndrome Scale浙江省医学会精神病学分会（The Society of Psychiatry,ZJMA）、浙江省医师协会精神科医师分会