PTEN Family in Tumor Suppression and Metabolism

PTEN tumor suppressor is one of the most frequently mutated genes in human cancers.PTEN has a wide range of biological functions beyond tumor suppression.In our recent studies,we have revealed a mechanism of alternative protein translation,through which we identified a PTEN isoform with novel functions.A CUG codon upstream of and in-frame with the coding region of canonical PTEN initiates translation of an N-terminally extended form of PTEN,which we have designated PTENa.We found that eukaryotic translation initiation factor 2A(eIF2A) controls PTEN synthesis and a CUG-centered palindromic motif is required in this process.PTEN induces cytochrome c oxidase activity and ATP production in mitochondria.TALEN-mediated somatic deletion of PTEN impairs mitochondrial respiratory chain function.PTEN physically interacts and collaborates with canonical PTEN to promote energy production.Our data provide insights into the mechanism by which the PTEN family is involved in multiple cellular processes.These results suggest ...PTEN tumor suppressor is one of the most frequently mutated genes in human cancers.PTEN has a wide range of biological functions beyond tumor suppression.In our recent studies,we have revealed a mechanism of alternative protein translation,through which we identified a PTEN isoform with novel functions.A CUG codon upstream of and in-frame with the coding region of canonical PTEN initiates translation of an N-terminally extended form of PTEN,which we have designated PTENa.We found that eukaryotic translatio国家外国专家局国外人才信息研究中心