Total Synthesis of Biologically Active Macrocyclic Natural Products

Structurally diverse and complex naturally derived macrocycles have demonstrated an impressive record of efficacy as pharmaceutical agents,and are playing an increasingly important role in the treatment of a range of serious diseases.These macrocycles have received intense recent interest from the medicinal chemistry community driven in part by their activity in biological systems,such as those mediated by protein–protein interactions,Structurally diverse and complex naturally derived macrocycles have demonstrated an impressive record of efficacy as pharmaceutical agents,and are playing an increasingly important role in the treatment of a range of serious diseases.These macrocycles have received intense recent interest from the medicinal chemistry community driven in part by their activity in biological systems,such as those mediated by protein–protein interactions,中国化学会