<正> Background To explore the effect of human osteopontin (hOPN) on the proliferation, transmigration and expression of matrix metallproteinase-2 (MMP-2) and matrix metallproteinase-9 (MMP-9) in osteosarcoma (OS) cells in vitro.Methods The prokaryotic-expression vector of hOPN was produced. hOPN was then subcloned into E coli BL21 (DE3) cells and purified with ProBondTM Columns. The proliferation, cell cycle and the expression of cyclin A in OS cells were investigated by using MTT assay, flow cytometry and0277-8
Osteopontin (OPN) plays a pivotal role in cancer cell invasion and metastasis. Although OPN has a la...
AIM: To investigate the role of osteopontin (OPN) and its splice variants in the proliferation of he...
Osteopontin (OPN) is a multifunctional protein secreted intracellularly and extracellularly by vario...
Background To explore the effect of human osteopontin (hOPN) on the proliferation, transmigration an...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumor...
Tumor malignancy is associated with several features such as proliferation ability and frequency of ...
Abstract Tumor cells frequently have pronounced effects on the skeleton including bone destruction, ...
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multi...
Osteopontin, SDF-1α, and MMP-2 are important secreted molecules involved in the pathophysiology of h...
Cell migration and degradation of the extracellular matrix (ECM) are crucial steps in tumor progress...
Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised bone matri...
Aims: This study investigates whether matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9...
Background/Aims: Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many...
Using a cDNA microarray, we identified osteopontin (OPN) as one of the genes upregulated in cultured...
Osteopontin (OPN) plays a pivotal role in cancer cell invasion and metastasis. Although OPN has a la...
AIM: To investigate the role of osteopontin (OPN) and its splice variants in the proliferation of he...
Osteopontin (OPN) is a multifunctional protein secreted intracellularly and extracellularly by vario...
Background To explore the effect of human osteopontin (hOPN) on the proliferation, transmigration an...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumor...
Tumor malignancy is associated with several features such as proliferation ability and frequency of ...
Abstract Tumor cells frequently have pronounced effects on the skeleton including bone destruction, ...
Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multi...
Osteopontin, SDF-1α, and MMP-2 are important secreted molecules involved in the pathophysiology of h...
Cell migration and degradation of the extracellular matrix (ECM) are crucial steps in tumor progress...
Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised bone matri...
Aims: This study investigates whether matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9...
Background/Aims: Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many...
Using a cDNA microarray, we identified osteopontin (OPN) as one of the genes upregulated in cultured...
Osteopontin (OPN) plays a pivotal role in cancer cell invasion and metastasis. Although OPN has a la...
AIM: To investigate the role of osteopontin (OPN) and its splice variants in the proliferation of he...
Osteopontin (OPN) is a multifunctional protein secreted intracellularly and extracellularly by vario...
Add to ORKG