Add to ORKGRadiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment. This paper reviews the techniques of most commonly used quantitative magnetic resonance imaging (qMRI) biomarkers (dynamic contrast enhanced, dynamic susceptibility contrast, and diffusion weighted imaging) and their applications in oncological trials. Challenges of incorporating qMRI biomarkers in oncological trials are discussed including understanding biological mechanisms revealed by MRI biomarkers, consideration of rigorous trial design and standardized implementation of qMRI protocols.Rad...
Abstract: Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissu...
Magnetic resonance imaging (MRI), after the administration of an extracellular, gadolinium-based con...
As anticancer therapies designed to target specific molecular pathways have been developed, it has b...
The central role of MRI in neuro-oncology is undisputed. The technique is used, both in clinical pra...
The authors discuss eight areas of quantitative MR imaging that are currently used (RECIST, DCE-MR i...
Objective: To elaborate the role of quantitative magnetic resonance imaging (MRI) parameters in the ...
Background and purpose: Improving the accuracy of brain tumour radiotherapy (RT) treatment planning ...
Quantitative imaging biomarkers (QIBs) are increasingly being incorporated into early phase clinical...
AbstractThis article describes methods and issues that are specific to the assessment of change in t...
PurposeA magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteri...
On May 3, 2008, a National Cancer Institute (NCI)-sponsored open consensus conference was held in To...
AbstractOn May 3, 2008, a National Cancer Institute (NCI)-sponsored open consensus conference was he...
This article describes methods and issues that are specific to the assessment of change in tumor cha...
Magnetic resonance imaging (MRI) is particularly attractive for clinical application in perfusion im...
Improving Cancer Biomarkers through Magnetic Resonance TechnologybyMatthew Luke ZierhutCancer is a c...
Abstract: Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissu...
Magnetic resonance imaging (MRI), after the administration of an extracellular, gadolinium-based con...
As anticancer therapies designed to target specific molecular pathways have been developed, it has b...
The central role of MRI in neuro-oncology is undisputed. The technique is used, both in clinical pra...
The authors discuss eight areas of quantitative MR imaging that are currently used (RECIST, DCE-MR i...
Objective: To elaborate the role of quantitative magnetic resonance imaging (MRI) parameters in the ...
Background and purpose: Improving the accuracy of brain tumour radiotherapy (RT) treatment planning ...
Quantitative imaging biomarkers (QIBs) are increasingly being incorporated into early phase clinical...
AbstractThis article describes methods and issues that are specific to the assessment of change in t...
PurposeA magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteri...
On May 3, 2008, a National Cancer Institute (NCI)-sponsored open consensus conference was held in To...
AbstractOn May 3, 2008, a National Cancer Institute (NCI)-sponsored open consensus conference was he...
This article describes methods and issues that are specific to the assessment of change in tumor cha...
Magnetic resonance imaging (MRI) is particularly attractive for clinical application in perfusion im...
Improving Cancer Biomarkers through Magnetic Resonance TechnologybyMatthew Luke ZierhutCancer is a c...
Abstract: Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissu...
Magnetic resonance imaging (MRI), after the administration of an extracellular, gadolinium-based con...
As anticancer therapies designed to target specific molecular pathways have been developed, it has b...