Clinical features and prognosis of 25 cases of soft tissue sarcoma with soft tissue me-tastasis

目的：分析软组织肉瘤（soft tissue sarcoma，STS）远隔软组织转移患者的临床特点、预后影响因素及不同治疗手段的疗效差异，为其临床诊疗提供参考。方法：收集2010年6月至2016年6月北京大学肿瘤医院骨与软组织肿瘤科收治的发生远隔软组织转移的STS患者25例。统计分析其临床病理特点及预后情况。结果：25例远隔软组织转移患者中同时性转移6例（24%），异时性转移者19例（76%），原发灶手术后到出现转移病灶的平均时间为45.3个月。转移灶最常见的部位是躯干，共18例（72%）患者，其次为头颈部5例（20%）。本组患者1年总生存率80%，3年总生存率33%，11例（44%）伴有肺转移患者3年总生存率较差，差异具有统计学意义。结论：STS远隔软组织转移患者中组织学分级2级、无肺转移者有更高的总生存率；新辅助化疗、手术为主的综合治疗是主要治疗方案，靶向治疗作为新的治疗手段呈现较好的疗效。Objective:To explore the outcome of soft tissue sarcoma (STS) on patients with soft tissue metastasis. Methods:We ana-lyzed 25 STS patients with soft tissue metastasis primarily localized on extremity and trunk. The study was conducted from June 2010 to June 2016 by retrospective analysis of the clinical and pathological characteristics of the patients. The assessed endpoints were overall survival. Results:Six patients (24%) had synchronous soft tissue metastasis, and 19 patients (76%) had metachronous metasta-sis. The average time for primary tumor recession of metastatic lesions was 45.3 months. Metastases were most common in parts of the trunk in 18 patients (72%), followed by the head and neck in 5 patients (20%). Eleven patients (44%) with lung metastasis had poor prognosis. Conclusion:STS occurred more rarely in soft tissue metastasis than in pulmonary metastasis. Neoadjuvant chemotherapy and surgical treatment were the major therapies employed. Targeted therapy as a new treatment rendered good results.中国科学引文数据库(CSCD)136-404