Recent advances on the encoding and selection methods of DNA-encoded chemical library

DNA-encoded chemical library (DEL) has emerged as a powerful and versatile tool for ligand discovery in chemical biology research and in drug discovery. Encoding and selection methods are two of the most important technological aspects of DEL that can dictate the performance and utilities of DELs. In this digest, we have summarized recent advances on the encoding and selection strategies of DEL and also discussed the latest developments on DNA-encoded dynamic library, a new frontier in DEL research. (C) 2016 Elsevier Ltd. All rights reserved.General Research Fund of the University Grants Committee of Hong Kong [17321916]; University of Hong Kong start-up fund; Seed Fund Program for Basic Research from the University of Hong KongSCI(E)ARTICLE3361-3692