Degradation, hemolysis, and cytotoxicity of silane coatings on biodegradable magnesium alloy

The major obstacle to the clinical use of magnesium alloys is their fast degradation behaviors. In the present study, the triethoxy(octyl)silane coatings were electrodeposited on magnesium alloy to improve the corrosion resistance and biocompatibility. The effects of the electrodeposition potential on the corrosion properties of the silane coatings were investigated. The resulted coatings were characterized by SEM, FTIR, surface hydrophobicity, in addition, the corrosion behaviors and biocompatibilities were also evaluated. The results indicated that the coatings deposited at -2.0 V were more corrosion resistant than the other two silane coatings. Furthermore, the silane coatings showed good biocompatibilities, as demonstrated by significant increased cell viability, reduced hemolysis and platelet adhesion. (C) 2017 Elsevier B.V. All rights reserved.NSFC [51401007, 11120101001, 11421202]; National Excellent Doctoral Dissertation of PR China [201463]; Research Fund for the Doctoral Program of Higher Education of China [20131102130004]; Beijing Natural Sciences Foundation [2154050]SCI(E)ARTICLE266-26919