Modelling envelope and temporal fine structure components of frequency-following responses in rat inferior colliculus

In studies of auditory perception, a dichotomy between envelope and temporal fine structure (TFS) has been emphasized. It has been shown that frequency-following responses (FFRs) in the rat inferior colliculus can be divided into the envelope component (FFREnv) and the temporal fine structure component (FFRTFS). However, the existing FFR models cannot successfully separate FFREnv and FFRTFS. This study was to develop a new FFR model to effectively distinguish FFREnv from FFRTFS by both combining the advantages of the two existing FFR models and simultaneously adding cellular properties of inferior colliculus neurons. To evaluate the validity of the present model, correlations between simulated FFRs and experimental data from the rat inferior colliculus were calculated. Different model parameters were tested, FFRs were calculated, and the parameters with highest prediction were chosen to establish an ideal FFR model. The results indicate that the new FFR model can provide reliable predictions for experimentally obtained FFREnv and FFRTFS.National Natural Science Foundation of China [31470987]; National Basic Research Development Program of China [2015CB351800]; "985" grants from Peking University for Physiological Psychology; China Post-doctoral Science Foundation [2016M601066]SCI(E)ARTICLE7966-9736