CHA(2)DS(2)-VASc score as predictor of ischemic stroke in patients undergoing coronary artery bypass grafting and percutaneous coronary intervention

Ischemic stroke following coronary revascularization procedures remains one of the most potentially devastating complications. CHA(2)DS(2)-VASc score has been widely used for stroke risk stratification in AF patients. The aim of this nationwide study was to examine the association between the CHA(2)DS(2)-VASc score and ischemic stroke following coronary revascularization procedures. We identified patients undergoing coronary revascularization procedures, coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI), using the electronic Hospitalization Summary Reports. Logistic regression models were applied to evaluate the association of CHA(2)DS(2)-VASc score with the risk of post-procedural ischemic stroke. We identified 54,714 patients undergoing CABG and 263,063 patients undergoing PCI from 2013 to 2015. The CHA(2)DS(2)-VASc score had a positive graded association with the risk of post-procedural ischemic stroke in both CABG and PCI (P for trend < 0.001). The adjusted risk of post-procedural ischemic stroke increased by an estimated 122.4% (odds ratio [OR], 2.22; 95% confidence interval [CI], 2.11-2.35) and 34.7% (OR, 1.35; 95% CI, 1.31-1.39) for each additional 1 point in the CHA(2)DS(2)-VASc score in CABG and PCI, respectively. In conclusion, these findings suggested that CHA(2)DS(2)-VASc score was an independent predictor of the development of post-procedural ischemic stroke in patients undergoing CABG and PCI.National Natural Science Fund Projects of China [81473043]SCI(E)ARTICLE