Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells (SSCs) produce haploid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, posttranscriptional, and translational levels. Here we report that N-6-methyladenosine (m(6)A), an epitranscriptomic mark regulating gene expression, plays essential roles during spermatogenesis. We present comprehensive m(6)A mRNA methylomes of mouse spermatogenic cells from five developmental stages: undifferentiated spermatogonia, type A(1) spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes, and round spermatids. Germ cell-specific inactivation of the m(6)A RNA methyltransferase Mettl3 or Mettl14 with Vasa-C...
Translation of stored mRNAs accounts for protein synthesis during the transcriptionally inactive sta...
METTL3 (methyltransferase-like 3) mediates the N6-methyladenosine (m6A) methylation of mRNA, which a...
Development of specific DNA methylation patterns is required for normal spermatogenesis. DNA methylt...
Abstract Proper follicle development is very important for the production of mature oocytes, which i...
Protein methyltransferases play various physiological and pathological roles through methylating his...
Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It...
N6-methyladenosine (m6A) is the most abundant modification on eukaryotic mRNA. m6A plays important r...
Epigenetics is defined as genomic modifications that alter gene expression without changing the nucl...
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transc...
The production of mature germ cells capable of generating totipotent zygotes is a highly specialized...
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. In recent ye...
International audienceInternal modification of RNAs with N-6-methyladenosine (m(6)A) is a highly con...
Abstract Background Cryopreservation induces transcriptomic and epigenetic modifications that strong...
Background: Formation of haploid spermatozoa capable of fertilization requires proper programming of...
N6-methyladenosine (m6A) is the most abundant modification on eukaryotic mRNA. m6A plays important r...
Translation of stored mRNAs accounts for protein synthesis during the transcriptionally inactive sta...
METTL3 (methyltransferase-like 3) mediates the N6-methyladenosine (m6A) methylation of mRNA, which a...
Development of specific DNA methylation patterns is required for normal spermatogenesis. DNA methylt...
Abstract Proper follicle development is very important for the production of mature oocytes, which i...
Protein methyltransferases play various physiological and pathological roles through methylating his...
Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It...
N6-methyladenosine (m6A) is the most abundant modification on eukaryotic mRNA. m6A plays important r...
Epigenetics is defined as genomic modifications that alter gene expression without changing the nucl...
N6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes degradation of transc...
The production of mature germ cells capable of generating totipotent zygotes is a highly specialized...
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. In recent ye...
International audienceInternal modification of RNAs with N-6-methyladenosine (m(6)A) is a highly con...
Abstract Background Cryopreservation induces transcriptomic and epigenetic modifications that strong...
Background: Formation of haploid spermatozoa capable of fertilization requires proper programming of...
N6-methyladenosine (m6A) is the most abundant modification on eukaryotic mRNA. m6A plays important r...
Translation of stored mRNAs accounts for protein synthesis during the transcriptionally inactive sta...
METTL3 (methyltransferase-like 3) mediates the N6-methyladenosine (m6A) methylation of mRNA, which a...
Development of specific DNA methylation patterns is required for normal spermatogenesis. DNA methylt...