P50 suppression deficits and psychopathology in Han Chinese patients with schizophrenia

Objective: Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patterns and their correlations with clinical symptoms in a large sample of Han Chinese patients with schizophrenia. Methods: We assessed P50 sensory gating with a 64-channel electroencephalography system in 133 patients with schizophrenia and 148 healthy controls. The schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS). Results: Patients with schizophrenia had a significantly higher P50 gating ratio (p < 0.001), longer S1 latency (p < 0.05), lower S1 amplitude (p < 0.01), and lower P50 difference (p < 0.001) than did controls. No significant correlations were found between the P50 gating measures and the PANSS total score or subscale scores in patients with schizophrenia. Conclusions: These findings suggest that the P50 sensory gating deficits identified in Chinese patients with schizophrenia may not be involved in the psychopathology of the illness. (C) 2017 Elsevier B.V. All rights reserved.Capital Medical Development and Research [2011-2013-02]; Beijing Municipal Science & Technology Commission [D121100005012005, Z141107002514016]; National Natural Science Foundation of China [81461130016]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [zy201409]SCI(E)SSCIARTICLE346-35065