RNA表观遗传修饰N6-甲基腺嘌呤(m6A)是真核生物信使RNA(mRNA)上存在的最为广泛的中间化学修饰.它在哺乳动物中存在较为广泛,证实m6A为mRNA上的动态可逆化修饰,它由甲基转移酶复合物(编码器)催化形成,同时可以被去甲基酶(消码器)氧化去甲基;m6A可以被结合蛋白(读码器)识别,进而调控mRNA的剪接、稳定性、翻译、出核等.相较之下,m6A在植物中的研究较少.本文将简要回顾目前m6A的研究进展,重点综述m6A在植物中的研究结果,展望m6A在植物生长发育和应对外界刺激时的潜在重要功能.国家重点研发计划“精准医学研究”重点专项41-103
There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome....
Plants coordinate their growth and development through complex regulatory networks involving changes...
Wydział BiologiiW przedstawionej pracy doktorskiej wykazałem że enzym zwany metylazą adenozyny mRNA ...
N~6-甲基腺嘌呤(N~6-methyladenosine, m~6A)是真核生物信使RNA(Messenger RNA, mRNA)上含量最多的化学修饰之一。类似于DNA和组蛋白化学修饰,m~6A修...
作为mRNA上最丰富的一种甲基化修饰，N6-甲基腺苷(N6-methyl-adenosine， m6A)广泛存在于酵母以及动植物中。然而多年来由于缺乏有效的技术手段，这些甲基化修饰发生在mRNA的什么...
该文选取牛胰核糖核酸酶（RNaseA）为模型蛋白，对聚乙二醇修饰蛋白的技术以及修饰对蛋白性质的影响做了较为系统的研究.实验采用单甲氧基聚乙二醇（MPEG）为修饰剂.该文优化了MPEG的N-羟在琥珀酰亚...
RNA modifications, which collectively constitute the epitranscriptome, have been found to play a cru...
Reichel M, Köster T, Staiger D. Marking RNA: m6A writers, readers and functions in Arabidopsis. Jour...
RNA modifications, which collectively constitute the epitranscriptome, have been found to play a cru...
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modi...
More than 100 types of chemical modifications in RNA have been well documented. Recently, several mo...
Vast emerging evidences are linking the base modifications and determination of stem cell fate such ...
生长素是最重要的植物激素之一,参与了植物生长发育的各个方面.植物体内游离的IAA是生长素的主要活性形式,在IAA甲基转移酶1(IAMT1)的作用下,IAA可以转变为IAA甲酯(MeIAA).MeIAA...
Plants coordinate their growth and development through complex regulatory networks involving changes...
In eukaryotic organisms, there are known more than 200 internal post-transcriptional modifications o...
There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome....
Plants coordinate their growth and development through complex regulatory networks involving changes...
Wydział BiologiiW przedstawionej pracy doktorskiej wykazałem że enzym zwany metylazą adenozyny mRNA ...
N~6-甲基腺嘌呤(N~6-methyladenosine, m~6A)是真核生物信使RNA(Messenger RNA, mRNA)上含量最多的化学修饰之一。类似于DNA和组蛋白化学修饰,m~6A修...
作为mRNA上最丰富的一种甲基化修饰，N6-甲基腺苷(N6-methyl-adenosine， m6A)广泛存在于酵母以及动植物中。然而多年来由于缺乏有效的技术手段，这些甲基化修饰发生在mRNA的什么...
该文选取牛胰核糖核酸酶（RNaseA）为模型蛋白，对聚乙二醇修饰蛋白的技术以及修饰对蛋白性质的影响做了较为系统的研究.实验采用单甲氧基聚乙二醇（MPEG）为修饰剂.该文优化了MPEG的N-羟在琥珀酰亚...
RNA modifications, which collectively constitute the epitranscriptome, have been found to play a cru...
Reichel M, Köster T, Staiger D. Marking RNA: m6A writers, readers and functions in Arabidopsis. Jour...
RNA modifications, which collectively constitute the epitranscriptome, have been found to play a cru...
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modi...
More than 100 types of chemical modifications in RNA have been well documented. Recently, several mo...
Vast emerging evidences are linking the base modifications and determination of stem cell fate such ...
生长素是最重要的植物激素之一,参与了植物生长发育的各个方面.植物体内游离的IAA是生长素的主要活性形式,在IAA甲基转移酶1(IAMT1)的作用下,IAA可以转变为IAA甲酯(MeIAA).MeIAA...
Plants coordinate their growth and development through complex regulatory networks involving changes...
In eukaryotic organisms, there are known more than 200 internal post-transcriptional modifications o...
There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome....
Plants coordinate their growth and development through complex regulatory networks involving changes...
Wydział BiologiiW przedstawionej pracy doktorskiej wykazałem że enzym zwany metylazą adenozyny mRNA ...
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