Clinicopathologic analysis of 15 lymphoepithelial carcinoma

目的:总结分析唾液腺淋巴上皮癌(lymphoepithelial carcinoma,LEC)的临床病理资料,为进一步提高诊治率提供参考.方法:对2006年1月-2016年9月诊治的15例LEC病例从流行病病因学、临床表现、诊断、治疗及预后等方面进行回顾性分析.结果:15例患者中,原发于腮腺8例,下颌下腺7例.男9例,女6例.发病年龄24～61岁,病程从20 d到10余年不等.患者中除1例来自黑龙江外,其他均来自中国南方.术后进行免疫组织化学检测,8例EB病毒原位杂交,阳检率为100％.术后随访13个月～10 a,除3例患者失访外,仅1例死亡,主要死亡原因为复发及转移.结论:唾液腺淋巴上皮癌是一种罕见的恶性肿瘤,颈淋巴转移率高.该病缺乏特征临床表现,需借助组织病理学检查予以确诊.治疗上首选根治性切除,手术无法彻底切除或淋巴结转移者术后辅助放疗,T3期及以上患者需辅助化疗.PURPOSE:To investigate the clinicopathologic features of lymphoepithelial carcinoma (LEC) of the salivary gland for improving the diagnostic and therapeutic strategies.METHODS:Fifteen cases with pathologically confirmed LEC from Jan 2006 to Sep 2016 were reviewed including clinicopathologic feature,etiology,diagnosis,treatment and prognosis.RESULTS:Among 15 cases,8 cases were located in the parotid gland and 7 in the submandibular gland,including 9 men and 7 women,aged from 24 to 61 year old.All patients came from south of China except 1 from Heilongjiang province.Immunohistochemical examination showed positive results of EB virus in 8 cases.One patient died of local recurrence or metastasis during 13 months to 10 years of follow-up,and 3 cases were lost to follow up.CONCLUSIONS:LEC is an extremely rare tumor in salivary gland,with extensive invasion and metastasis potential Differential diagnosis of this disease is depended on histology.Radical resection was considered as the primary treatment.Radiotherapy should be given to cases with residual tumor or metastasis.3273-2761