Progress of diagnosis and treatment schemes of Helicobacter pylori infection

幽门螺杆菌(Helicobacter pylori,H.pylori)对抗生素的耐药日益严重,既往的治疗方案难以满足临床需要.改进三联、四联疗法及其他新方案于临床中广泛研究,包括抗生素的重新选择、PPI的优化、疗程的延长、新的药物组合等.但由于各地耐药率背景的差异,各疗法所取得的疗效也不尽一致,多数改良方案在我国大陆地区并未取得满意疗效.个体化治疗、天然药物或可成为提高根除率的路径.Antibiotic resistance of Helicobacter pylori (H.pylori) has been increasingly serious, which led to treatment failure of present therapies.Improved triple, quadruple and other new therapies have been tested or observed in clinic.These improvements include renewing antibiotics and PPIs, prolonging duration and formulating new regimens.However, the efficacy of these therapies is not constant in different regions due to different antibiotic resistant rates.Many of these improved schemes failed to achieve satisfactory efficacy in Chinese mainland area.The individual therapy and natural medicines might be new pathways of increasing eradication rate.国家自然科学基金面上项目6644-6482