Analysis of a case of drug-induced hypersensitivity syndrome and review of related clinical progress

目的:对1例药物超敏反应综合征病例的致敏药物进行探讨.方法:通过查询该患者的病程记录、执行医嘱、护理记录单,结合有关超敏反应综合征的文献资料,对可疑药物进行分析,并探讨引起药物超敏反应综合征的原因及临床进展.结果:患者的死亡原因高度怀疑与别嘌醇相关.结论:药物超敏反应发病严重且危及生命,临床工作中应做到对药物超敏反应的早识别、早治疗;对于高危药物的使用,临床工作中需密切监护,以确保药物治疗的安全.Objective: To analyze the causative drugs of a case of drug-induced hypersensitivity syndrome (DIHS/DRESS). Methods: According to the medical records, doctor's orders, and nursing records of the patient, the authors analyzed the causative drugs and the cause of DRESS and explored the clinical progress of DRESS by referring to related literature. Suggestions for clinical treatment were provided. Results: The cause of the patient's death was suspected to be highly associated with allopurinol. Conclusion: DRESS is severe and life-threatening. We should achieve early identification and treatment of DRESS in the clinical practice; the use of high-risk drugs should be monitored closely in the clinical practice in order to ensure the safety of therapeutic drugs.780-841