Polymer-based monolithic column with incorporated chiral metal-organic framework for enantioseparation of methyl phenyl sulfoxide using nano-liquid chromatography

A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal-organic framework for nano-liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4-vinylpyridine-co-ethylene dimethacrylate) column, excellent separations of both enantiomers of (+/-)methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metalorganic framework [Zn-2(benzene dicarboxylate)(l-lactic acid)(dmf)], which is synthesized from zinc nitrate, L-lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography.National Natural Science Foundation of China [2152780016, 21175008]; Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy [DE-AC02-05CH11231]SCI(E)PubMedARTICLEfsvec@lbl.gov; hwliu@pku.edu.cn234544-45483