Temperature-dependent elastic properties of brain tissues measured with the shear wave elastography method

Determining the mechanical properties of brain tissues is essential in such cases as the surgery planning and surgical training using virtual reality based simulators, trauma research and the diagnosis of some diseases that alter the elastic properties of brain tissues. Here, we suggest a protocol to measure the temperature-dependent elastic properties of brain tissues in physiological saline using the shear wave elastography method. Experiments have been conducted on six porcine brains. Our results show that the shear moduli of brain tissues decrease approximately linearly with a slope of -0.041 +/- 0.006 kPa/degrees C when the temperature T increases from room temperature (similar to 23 degrees C) to body temperature (similar to 37 degrees C). A case study has been further conducted which shows that the shear moduli are insensitive to the temperature variation when T is in the range of 37 to 43 degrees C and will increase when T is higher than 43 degrees C. With the present experimental setup, temperature-dependent elastic properties of brain tissues can be measured in a simulated physiological environment and a non-destructive manner. Thus the method suggested here offers a unique tool for the mechanical characterization of brain tissues with potential applications in brain biomechanics research.National Natural Science Foundation of China [11172155, 11572179, 11432008]SCI(E)PubMedARTICLE652-6566