Association between serum albumin and cognitive performance in elderly Chinese

目的 研究老年人群血浆白蛋白水平与认知功能的关系.方法 选取中国老年健康影响因素跟踪调查中8个长寿地区所有≥65岁老年人为研究对象,通过入户问卷调查、健康体检,收集人口学变量、行为生活方式及健康状况,采用简易认知功能量表评定认知功能.收集空腹静脉血样检测白蛋白等生物指标.利用广义线性模型分析不同白蛋白水平的研究对象认知功能评分及变化趋势.以是否认知受损为因变量,利用多因素logistic回归模型,分析血浆白蛋白水平与认知受损的关系.结果 广义线性模型分析表明,随着白蛋白水平的升高,调整后的认知功能评分显著增加,从最低组的23.22升高到最高组的25.07,且有线性趋势(P＜0.001).logistic回归分析表明,较高的白蛋白水平与较低的认知受损风险显著相关(P＜0.001),相对于最低水平组,白蛋白较低、较高和最高水平组的认知受损OR值(95％CI)分别为0.64(0.45～ 0.91)、0.60(0.40 ～0.89)和0.43(0.27～0.69),具有线性下降趋势,差异有统计学意义(P＜0.01).结论 老年人群血浆白蛋白水平与认知受损的风险反向相关.Objective To explore association between serum albumin level and cognitive performance in elderly Chinese.Methods All the subjects aged ≥65 years in the 8 longevity areas in Chinese longitudinal health longevity survey (CLHLS) were invited to participate the biomedical in-depth CLHLS study,information about subjects' demographic characteristics,lifestyle,prevalence of diseases and health status was collected through household-interview.The cognitive performance was assessed with Mini Mental State Evaluation (MMSE) scale.Health examination was conducted by medical personnel and fasting venous blood samples were collected to detect the levels of triglycerides,total cholesterol,fasting glucose,creatine and blood albumin.MMSE score was compared and the trend was analyzed with generalized linear model.Association between albumin concentration and cognitive impairment was analyzed by logistic regression model.Results Generalized linear model showed that adjusted MMSE score increased from 23.22 in the lowest quartile group to 25.07 in the highest quartile group (P for linear trend ＜0.001).Logistic regression analysis results showed that the higher albumin level was associated with the lower risk of cognitive impairment (P＜ 0.001),the OR decreased linearly with the increasing level of albumin (P＜0.01),with the OR (95％CI) for the lower,higher and highest quartile groups was 0.64(0.45-0.91),0.60(0.40-0.89) and 0.43 (0.27-0.69),respectively,compared with the lowest quartile group.Conclusion High level of serum albumin was associated with low risk of cognitive impairment.国家自然科学基金; 联合国人口基金; National Natural Science Foundation of China; United Nations Population FundPubMed中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)101323-13263