Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes

Chu, Wen-Dao
Zhang, Lei
Zhang, Zhikun
Zhou, Qi
Mo, Fanyang
Zhang, Yan
Wang, Jianbo

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Publication date

January 2016

DOI

10.1021/jacs.6b09674

Publisher

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ISSN

0002-7863

Journal

issn:0002-7863

Citation count (estimate)

Abstract

A highly enantioselective synthesis of trisubstituted allenes has been achieved through Cu(I)-catalyzed cross-coupling of aryldiazoalkanes and terminal alkynes with chiral bisoxazoline ligands. Alkynyl migratory insertion of Cu(I) carbene is proposed as the key step for the construction of axial chirality.National Basic Research Program of China (973 Program) [2015CB856600]; Natural Science Foundation of China [21472004, 21332002]SCI(E)PubMedARTICLEwangjb@pku.edu.cn4414558-1456113

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Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes

Abstract

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Enantioselective Synthesis of Trisubstituted Allenes via Cu(I)-Catalyzed Coupling of Diazoalkanes with Terminal Alkynes

Abstract

Extracted data

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