IL-6-mediated functional up-regulation of TRPV1 receptors in DRG neurons via the activation of JAK/PI3K signaling pathway:roles in the development of bone cancer pain in a rat model

Objective Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain. The mechanisms underlying the pathogenesis of bone cancer pain still remain largely unknown. Previously, we have reported that sensitization of primary sensory dorsal root ganglion(D...Objective Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain. The mechanisms underlying the pathogenesis of bone cancer pain still remain largely unknown. Previously, we have reported that sensitization of primary sensory dorsal root ganglion(D...中国神经科学学会