In Vitro Evaluation of the Feasibility of Commercial Zn Alloys as Biodegradable Metals

In this work, three widely used commercial Zn alloys (ZA4-1, ZA4-3, ZA6-1) were purchased and prepared by hot extrusion at 200 degrees C. The microstructure, mechanical properties, corrosion behaviors, biocompatibility and hemocompatibility of Zn alloys were studied with pure Zn as control. Commercial Zn alloys demonstrated increased strength and superb elongation compared with pure Zn. Accelerated corrosion rates and uniform corrosion morphologies were observed in terms of commercial Zn alloys due to galvanic effects between Zn matrix and a alpha-Al phases. 100% extracts of ZA4-1 and ZA6-1 alloys showed mild cytotoxicity while 50% extracts of all samples displayed good biocompatibility. Retardant cell cycle and inhibited stress fibers expression were observed induced by high concentration of Zn2+ releasing during corrosion. The hemolysis ratios of Zn alloys were lower than 1% while the adhered platelets showed slightly activated morphologies. In general, commercial Zn alloys possess promising mechanical properties, appropriate corrosion rates, significantly improved biocompatibility and good hemoconipatibility in comparison to pure Zn. It is feasible to develop biodegradable metals based on commercial Zn alloys. Copyright (C) 2016, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.National Basic Research Program of China (973 Program) [2012CB619102, 012CB619100]; National Science Fund for Distinguished Young Scholars [51225101]; National Natural Science Foundation of China [51431002, 31170909]; NSFC/RGC joint Research Scheme [51361165101]; State Key Laboratory for Mechanical Behavior of Materials [20141615]; Beijing Municipal Science and Technology Project [Z141100002814008]SCI(E)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)ARTICLExuanli@vip.sina.com; yfzheng@pku.edu.cn9909-9183