SYNTHESIS AND CHARACTERIZATION OF N~2-(1-CARBOXYETHYL)-GUANOSINE AND N~2-CARBOXYMETHYL-GUANOSINE AS AUTHENTIC ADVANCED GLYCATION END PRODUCTS OF GUANOSINE

Methylglyoxal(MG)is a highly reactiveα-oxoaldehyde which is formed endogenously from a great deal of physiological processes.In diabetes,hyperglycemia leads to enhanced production of MG,which triggers rapid modification of proteins,DNA and other substrates to generate advanced glycation end produ...Methylglyoxal(MG)is a highly reactiveα-oxoaldehyde which is formed endogenously from a great deal of physiological processes.In diabetes,hyperglycemia leads to enhanced production of MG,which triggers rapid modification of proteins,DNA and other substrates to generate advanced glycation end produ...China Association for Instrumental Analysis