IDENTIFICATION OF SHORT OLIGODEOXYNULEOTIDE ADDUCTS OF METHYLGLYOXAL BY LC-MS/MS

Methylglyoxal(MG)is a highly reactive 1,2-dicarbonyl compound,which can be endogenously formed during metabolism of glycolysis,ketone and catabolism of threonine[1-2].It is proved that accumulation of MG in mammalian cells can cause stable modifications of DNA bases thereby induceMethylglyoxal(MG)is a highly reactive 1,2-dicarbonyl compound,which can be endogenously formed during metabolism of glycolysis,ketone and catabolism of threonine[1-2].It is proved that accumulation of MG in mammalian cells can cause stable modifications of DNA bases thereby induceChina Association for Instrumental Analysis