Kruppel-like factors:emerging regulators mediating the anti-atherogenic effects of flow shear stress

Mechanical forces such as flow shear stress and cyclic stress contribute to vascular homeostasis and determine the anatomical distribution of atherosclerotic lesions.However,the molecular pathways that mediate the mechanical signaling remain poorly understood.Kr(?)ppel-like factors(KLFs),a family...Mechanical forces such as flow shear stress and cyclic stress contribute to vascular homeostasis and determine the anatomical distribution of atherosclerotic lesions.However,the molecular pathways that mediate the mechanical signaling remain poorly understood.Kr(?)ppel-like factors(KLFs),a family...中国病理生理学会1Vol.2