Site-directed Mutation of Trichosanthin And Its Anti-tumor Activity

Introduction Trichosanthin(TCS)is a ribosome-inactivating protein(RIPs)extracted from Trichosanthes kirilowii,a Chinese herb medicine,with multiple biological and pharmacological properties,including abortifacient,anti-tumor and anti-virus activities[1].It was known that TCS belonged to type-I RI...Introduction Trichosanthin(TCS)is a ribosome-inactivating protein(RIPs)extracted from Trichosanthes kirilowii,a Chinese herb medicine,with multiple biological and pharmacological properties,including abortifacient,anti-tumor and anti-virus activities[1].It was known that TCS belonged to type-I RI...中国微生物学会酶工程专业委员会（Chinese Society for Enzyme Engineering）、Japanese Society for Enzyme Engineering