Identification of PEAR1 single-nucleotide polymorphisms and their influences on the variation in Prasugrel pharmacodynamics

Aim:The platelet responses to antiplatelet drugs are highly variable.However, the associated mechanisms are poorly defined.The present study aimed to investigate PEAR1 genetic polymorphisms and pharmacogenetic variability in the pharmacodynamics of prasugrel,a new oral antiplatelet agent,in 36 he...Aim:The platelet responses to antiplatelet drugs are highly variable.However, the associated mechanisms are poorly defined.The present study aimed to investigate PEAR1 genetic polymorphisms and pharmacogenetic variability in the pharmacodynamics of prasugrel,a new oral antiplatelet agent,in 36 he...1Vol.3