CPVT-related mutation increased RyR2 channel sensitivity to calcium influx through L-type calcium channels

Catecholaminergic polymorphic ventricular tachycardia(CPVT) is an arrhythmogenic cardiomyopathy that manifests as recurrent syncope and sudden cardiac death triggered by high adrenergic tone.Mutations in the cardiac ryanodine receptor(RyR2) are known to be the predominant genetic causes of CPVT.H...Catecholaminergic polymorphic ventricular tachycardia(CPVT) is an arrhythmogenic cardiomyopathy that manifests as recurrent syncope and sudden cardiac death triggered by high adrenergic tone.Mutations in the cardiac ryanodine receptor(RyR2) are known to be the predominant genetic causes of CPVT.H...中国科学院上海生命科学研究院(Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences)、中国生理学会(Chinese Association for Physiolog1VOL.6