Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors
- Yu, Fei
- Wang, Qi
- Wang, Han
- Si, Long-Long
- Liu, Jia-Xin
- Han, Xu
- Xiao, Su-Long
- Zhang, Li-He
- Zhou, De-Min
Publication date
January 2016
DOI Publisher
CHINESE CHEMICAL LETTERS ISSN
1001-8417 Journal
1001-8417 Citation count (estimate)
2Abstract
A series of echinocystic acid (EA) 28-COOH derivatives was synthesized, and their anti-HCV entry activity was evaluated by HCVpp and VSVpp entry assay. It was found that some of them showed moderate anti-HCV entry activity, especially compound 12, and these modifications also removed the undesired hemolytic effect. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.supported by the National Natural Science Foundation of China,Open- Fund Program of the State Key Laboratory of Natural and Biomimetic Drugs,Yunnan Basic Research ProjectSCI(E)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)ARTICLEfeiyuz8@163.com; deminzhou@bjmu.edu.cn5711-7132
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