Healing of cancellous fracture in a novel mouse model

Fractures are one of the most prevalent clinical conditions worldwide. Among them, cancellous fracture is a major cause of extremities fractures. Unfortunately, it is largely unknown about how is the healing of cancellous fracture. In the current study, we present a novel cancellous fracture mice model, which successfully mimic clinical cancellous fracture scenario. Next, we showed that the newly repaired trabeculae in fracture healing zone were thicker than normal bone tissue with more sufficient local blood supply. There are more osteoclasts reside in the fracture healing zone than normal bone tissue and these osteoclasts distributed more closely and densely. Moreover, the early repairing bone mass in fracture healing zone was not fully collagen loaded as normal bone tissue. Comparing to similar cell proliferation activity, upreguiated local cell function play more important role in the cancellous fracture repair.Chinese National Ministry of Science and Technology 973 Project Planning [2014CB542200, 2014-CB542206]; 863 project [SS2015AA020-501]; ministry of education innovation team [IRT1201]; National Natural Science Fund [31271284, 31171150, 81171146, 30971526, 31100860, 31040043]; Educational Ministry New Century Excellent Talents Support Project [BMU20110270]SCI(E)PubMedARTICLEzhangpeixun@bjmu.edu.cn; jiangbaoguo@vip.sina.com112279-2290