Pd(0)-catalyzed cross-coupling of allyl halides with alpha-diazocarbonyl compounds or N-mesylhydrazones: synthesis of 1,3-diene compounds

With palladium catalysis, allyl bromides or chlorides react with alpha-diazocarbonyl compounds or N-mesylhydrazones to afford 1,3-diene derivatives. The reaction represents a novel and efficient method for the synthesis of 1,3-butadiene derivatives. Mechanistically, the reaction is proposed to follow a pathway involving the formation of a pi-allylic palladium carbene complex and subsequent migratory insertion.National Basic Research Program of China (973 Program) [2012CB821600]; National Natural Science Foundation of China [21472004, 21332002]SCI(E)EIPubMedARTICLEwangjb@pku.edu.cn153809-38201