Four new minor brominated indole related alkaloids with antibacterial activities from Laurencia similis

Four new minor brominated indole related alkaloids (one indoles, 1, one 1,3-dihydro-indole-2-one, 2, one carbazole, 3, and one 2-carbonylamino-benzoate, 4) were isolated and identified from Laurencia similis by extensive chromatographic and spectrometric methods. Among them, 1 and 2 were the first example of naturally occurring indole with 3-benzyl group and 1,3-dihydro-indole-2-one with 2-isopropylidene group, respectively, whereas 3 and 4 were the first carbazole alkaloids and 2-carbonylamino-benzoate, respectively, isolated from the genus Laurencia. Moreover, 1 showed the most potent antibacterial activity against seven bacterial strains with MIC values ranging from 2 to 8 mu g/mL. (C) 2016 Elsevier Ltd. All rights reserved.National Natural Science Foundation of China [21172008]; Union Opening Foundation of CAS' Key Laboratory of Marine Bioresources Sustainable Utilization (LMB); Guangdong key Laboratory of Marine Materia Medica (LMM)SCI(E)PubMedARTICLEqyzhang@hsc.pku.edu.cn153590-35932