Investigation of relationship between schizophrenia and ten kinds of elements in serum

目的：探讨精神分裂症患者血清中10种元素含量变化与疾病的关系。方法采用电感耦合等离子体质谱仪和电感耦合等离子体发射光谱仪对精神分裂症患者和正常人血清中的钙（Ca）、镁（Mg）、锌（Zn）、铁（Fe）、铝（Al）、砷（As）、硒（Se）、铜（ Cu）、铅（ Pb）、锰（ Mn）进行测定，对其含量进行比较分析。结果除铅外，其余元素在2组间差异有统计学意义（ P＜0.05），精神分裂症患者血清中Ca、Fe、Mg、Zn、As、Se、Cu含量显著低于对照组，而Al、Mn的含量显著高于对照组；病例组和对照组血清中10种元素间大多均存在相关关系（P＜0.05）；某些有生理学意义的元素比在2组间差异有统计学意义（P＜0.05）。如：Ca／Mg、Ca／Fe等。结论精神分裂症患者可能存在生命元素的代谢异常，鉴于元素间的相互关系，元素比在反映精神分裂症与元素的关系方面更有价值。Objective To study the relationship between the changes of ten elemental contents in serum and schizophrenia.Methods Calcium (Ca), magnesium (Mg), zinc (Zn), iron (Fe), aluminum (Al), arsenic (As), selenium (Se), copper (Cu), lead (Pb), manganese (Mn) in serum in the of schizophrenic patients and normal subjects are measured by inductively coupled plasma mass spectrometer and inductively coupled plasma emission spectrometer, compared the content of elements between the schizophrenia and normal.Results There were significant differences ( P<0.05) in other elements between two groups except lead.The contents of Ca,Fe,Mg,Zn,As,Se,Cu in the patients with schizophrenia were significantly lower than those in control, while Al, Mn were significantly higher than those in control.Most of elements in serum between case and control groups were correlated (P<0.05).Some of element ratios which have physiological significance were significant statistically (P<0.05), such as: Ca/Mg, Ca/Fe and so on.Conclusion These findings suggest that the patients with schizophrenia might have an abnormal elemental metabolism.Given the relationship among the elements, the element ratios are more valuable in reflecting the relationship between schizophrenia and elements.655-5