Special algorithm for stability analysis of multistable biological regulatory systems

We consider the problem of counting (stable) equilibriums of an important family of algebraic differential equations modeling multistable biological regulatory systems. The problem can be solved, in principle, using real quantifier elimination algorithms, in particular real root classification algorithms. However, it is well known that they can handle only very small cases due to the enormous computing time requirements. In this paper, we present a special algorithm which is much more efficient than the general methods. Its efficiency comes from the exploitation of certain interesting structures of the family of differential equations. (C) 2014 Elsevier Ltd. All rights reserved.US National Science Foundation [1319632]; China Scholarship Council [201206010094]; National Science Foundation of China [11290141, 11271034]; NIMS Thematic Program on Applied Algebraic GeometrySCI(E)ARTICLEhong@ncsu.edu; tangxiaoxian@pku.edu.cn; xbc@math.pku.edu.cn112-1357