Preparation of 188Re-HEDP lyophilized kit for instant bone metastases therapy

Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of 188Re-HEDP. 188Re-HEDP showed high focile uptake in normal mice (> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.Supported by the National Natural Science Foundation of China,Beijing Natural Science Foundation中国科学引文数据库(CSCD)660302-1-60302-62