Research on exposure to polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth

多环芳烃（PAH）是广泛存在于环境中的有毒污染物，可以通过呼吸道、消化道等多种方式进入人体。孕妇和新生儿是重要的敏感人群，相关的研究证据表明孕期PAH暴露可能是早产发生的重要原因，但具体的作用机制不是十分明确，可能与DNA损伤、氧化应激、全身炎症反应、内分泌干扰等有关。本文就孕期PAH暴露的影响因素和评价方法、孕期PAH暴露可增加早产的发生风险和可能的作用机制进行了综述。Polycyclic aromatic hydrocarbons(PAH) are a group of toxic pollutants existing in the environment widely, and can be taken into the body through various ways containing the digestive tract, respiratory tract and so on. Pregnant women and newborn infants are important and susceptive populations. Relevant study evidences indicate that exposure to PAH during pregnancy may be a important risk factor of preterm delivery, but the special mechanism isn't very clear and may be related with DNA damage, oxidative stress, systemic inflammation, endocrine disruption and so on. This paper reviewed related contents including the influences and evaluation methods of exposure to PAH during pregnancy, increasing risk and potential mechanism for preterm delivery of exposure to PAH during pregnancy .国家自然科学基金PubMed中文核心期刊要目总览(PKU)中国科技核心期刊(ISTIC)中国科学引文数据库(CSCD)7665-6684