Study on synthesis of (R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine

Tang, Lin Jun
Lv, Chang Shan
Liu, Dong Wang
Feng, Jun Min
Chen, Shi Peng
Zhang, Jian Ting
Wang, Xiao Ji
Huang, Shuang Ping

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Publication date

January 2013

DOI

10.4028/www.scientific.net/AMR.781-784.1180

ISSN

1662-8985

Abstract

(R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine, an intermediate of the natural product jaspine B, which was isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized from L-Serine in overall yield 43% through seven steps, including esterification, Boc protection, acetonization, reduction, Swern oxidation and Corey-Fuchs reaction. ? (2013) Trans Tech Publications, Switzerland.EI

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Study on synthesis of (R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine

Abstract

Extracted data

Study on synthesis of (R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine

Abstract

Extracted data

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