Exploring an expedient IMDA reaction approach to construct the guanacastepene core

[graphics] Construction of the [5-7-6] tricyclic core of guanacastepenes was attempted by using the intramolecular Diels-Alder (IMDA) reaction and Me3Al-mediated ring opening of the oxabridge as key synthetic steps. The illustrated chemistry demonstrated a synthetic feasibility to build up the framework of guanacastepenes by the IMDA reaction.Chemistry, OrganicSCI(E)26ARTICLE173709-3712