siRNA has become an indispensable tool for functional characterization of genes. It has also demonstrated tremendous potential as a new generation of drug candidates. Although the technology works very well to a great panel of cells in vitro, it is still a challenge to translate the success into in vivo target validation easiness and, even more difficult, into therapeutic applications. With a number of chemically modified compounds under initial clinical trial from several commercial entities, the interests in chemical modification of siRNA have become heightened. In this review we have tried to touch on most of the chemical modifications of RNA that have been tested in the siRNA landscape, but maintained a focus on the backbone modificatio...
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 ch...
Title: "Structural and biochemical evaluation of natural and modified Nucleic Acids and their intera...
Design of small interfering RNA (siRNA) is a basic step to successful RNA interference (RNAi). Howev...
RNA interference technology has become a powerful laboratory tool to study gene function. Small inte...
Small interfering RNAs (siRNAs) are one of the valuable tools to investigate the functions of genes ...
Various chemical modifications were created in short-interfering RNAs (siRNAs) to determine the bioc...
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice ...
The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in th...
The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in th...
Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function i...
Short interfering RNAs (siRNAs) are biomolecules used for post-transcriptional gene regulation, and ...
Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silenci...
Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ...
Advances in the chemical synthesis of RNA have opened new possibilities to address current questions...
Small interfering (si)RNAs have recently been used to therapeutically silence genes in vivo after in...
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 ch...
Title: "Structural and biochemical evaluation of natural and modified Nucleic Acids and their intera...
Design of small interfering RNA (siRNA) is a basic step to successful RNA interference (RNAi). Howev...
RNA interference technology has become a powerful laboratory tool to study gene function. Small inte...
Small interfering RNAs (siRNAs) are one of the valuable tools to investigate the functions of genes ...
Various chemical modifications were created in short-interfering RNAs (siRNAs) to determine the bioc...
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice ...
The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in th...
The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in th...
Small interfering RNAs (siRNAs) are now established as the preferred tool to inhibit gene function i...
Short interfering RNAs (siRNAs) are biomolecules used for post-transcriptional gene regulation, and ...
Small interfering RNA (siRNA) are non-coding, double-stranded RNA that enable efficient gene silenci...
Chemical modifications aimed at stabilizing the interaction between the 3'-end of siRNAs and the PAZ...
Advances in the chemical synthesis of RNA have opened new possibilities to address current questions...
Small interfering (si)RNAs have recently been used to therapeutically silence genes in vivo after in...
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 ch...
Title: "Structural and biochemical evaluation of natural and modified Nucleic Acids and their intera...
Design of small interfering RNA (siRNA) is a basic step to successful RNA interference (RNAi). Howev...