PFKFB3 is the gene that codes for the inducible isoform of 6-phosphofructo-2-kinase (iPFK2), a key regulatory enzyme of glycolysis. As one of the targets of peroxisome proliferator-activated receptor gamma (PPAR gamma), PFKFB3/iPFK2 is up-regulated by thiazolidinediones. In the present study, using PFKFB3/iPFK2-disrupted mice, the role of PFKFB3/iPFK2 in the anti-diabetic effect of PPAR gamma activation was determined. In wild-type littermate mice, PPAR gamma activation (i.e. treatment with rosiglitazone) restored euglycemia and reversed high fat diet-induced insulin resistance and glucose intolerance. In contrast, PPAR gamma activation did not reduce high fat diet-induced hyperglycemia and failed to reverse insulin resistance and glucose i...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
The nuclear receptors peroxisome proliferator-activated receptors (PPARs) play a key role in the reg...
Increasing evidence demonstrates the dissociation of fat deposition, the inflammatory response, and ...
Overnutrition causes many metabolic diseases including type 2 diabetes. PFKFB3/iPFK2 is a master reg...
AbstractObesity-associated diabetes is epidemic in industrialized societies. The nuclear receptor pe...
Peroxisome proliferator receptor gamma (PPARγ) is a nuclear receptor first identified for its role i...
The thiazolidinedione class of insulin-sensitizing, antidiabetic drugs interacts with peroxisome pro...
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nutrient-sensing transcription fa...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Type 2 diabetes develops in the context of both insulin resistance and beta-cell failure. Thiazolidi...
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nutrient-sensing transcription fa...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
The nuclear receptors peroxisome proliferator-activated receptors (PPARs) play a key role in the reg...
Increasing evidence demonstrates the dissociation of fat deposition, the inflammatory response, and ...
Overnutrition causes many metabolic diseases including type 2 diabetes. PFKFB3/iPFK2 is a master reg...
AbstractObesity-associated diabetes is epidemic in industrialized societies. The nuclear receptor pe...
Peroxisome proliferator receptor gamma (PPARγ) is a nuclear receptor first identified for its role i...
The thiazolidinedione class of insulin-sensitizing, antidiabetic drugs interacts with peroxisome pro...
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nutrient-sensing transcription fa...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Type 2 diabetes develops in the context of both insulin resistance and beta-cell failure. Thiazolidi...
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nutrient-sensing transcription fa...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that ...
The nuclear receptors peroxisome proliferator-activated receptors (PPARs) play a key role in the reg...