Aim: The aim of this study was to establish drug-resistant cell lines and to elucidate mechanisms leading to multi-drug resistance in gastric cancer. Materials and Methods: Five cancer cell lines resistant to 5-fluorouracil, paclitaxel, oxaliplatin, irinotecan, or gemcitabine, were respectively established from a parent gastric cancer cell line, OCUM-2M, by stepwise exposure to each chemotherapeutical agent. Results: Cell death by apoptosis induced by anti-cancer drugs was low in 5 chemo-resistant cell lines. Percentage of cells in S and G(0)/G(1) phase was low in cell lines resistant to oxaliplatin or irinotecan. Cell lines resistant to paclitaxel, oxaliplatin, and gemcitabine showed multi-drug resistance. Alterations in MRP, DAPK1, or DAP...
[[abstract]]To identify mechanisms underlying oxaliplatin resistance, a subline of the human gastric...
Human gastric cancer is a big public health problem. Multidrug resistance is a main obstacle to succ...
Current standard treatments for metastatic colorectal cancer (CRC) are based on combination regimens...
Aim: The aim of this study was to clarify the ability of a FGFR2 inhibitor, Ki23057, to enhance the ...
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. The most used chemothe...
The development of resistance to antineoplastic drugs is a major obstacle in the treatment of cancer...
AIM: To explore the reversal effect of mifepristone on multidrug resistance (MDR) in drug-resistant ...
Despite many effective therapies for gastro-intestinal (GI) cancers, both primary and acquired mecha...
To identify chemoresistance-associated secretory proteins by proteomic approaches, and to provide th...
Introduction: In order to determine the multidrug resistance (MDR) phenotype due to P-glycoprotein e...
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug resistance (MD...
Cancer chemotherapy with taxol often fails due to acquired resistance of cancer cells, which is freq...
Gastric cancer (GC) is the fifth most common malignancy worldwide and the third leading cause of can...
Gastric cancer is a leading cause of death in Asia and a heterogeneous disease. The aim of targeted...
Multidrug Resistance is a major obstacle in cancer chemotherapy. The current study was designed to e...
[[abstract]]To identify mechanisms underlying oxaliplatin resistance, a subline of the human gastric...
Human gastric cancer is a big public health problem. Multidrug resistance is a main obstacle to succ...
Current standard treatments for metastatic colorectal cancer (CRC) are based on combination regimens...
Aim: The aim of this study was to clarify the ability of a FGFR2 inhibitor, Ki23057, to enhance the ...
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. The most used chemothe...
The development of resistance to antineoplastic drugs is a major obstacle in the treatment of cancer...
AIM: To explore the reversal effect of mifepristone on multidrug resistance (MDR) in drug-resistant ...
Despite many effective therapies for gastro-intestinal (GI) cancers, both primary and acquired mecha...
To identify chemoresistance-associated secretory proteins by proteomic approaches, and to provide th...
Introduction: In order to determine the multidrug resistance (MDR) phenotype due to P-glycoprotein e...
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug resistance (MD...
Cancer chemotherapy with taxol often fails due to acquired resistance of cancer cells, which is freq...
Gastric cancer (GC) is the fifth most common malignancy worldwide and the third leading cause of can...
Gastric cancer is a leading cause of death in Asia and a heterogeneous disease. The aim of targeted...
Multidrug Resistance is a major obstacle in cancer chemotherapy. The current study was designed to e...
[[abstract]]To identify mechanisms underlying oxaliplatin resistance, a subline of the human gastric...
Human gastric cancer is a big public health problem. Multidrug resistance is a main obstacle to succ...
Current standard treatments for metastatic colorectal cancer (CRC) are based on combination regimens...