Lumped Parameter Model for Heart Failure with Novel Regulating Mechanisms of Peripheral Resistance and Vascular Compliance

To research the change in the physiological mechanism between the heart failure (HF) patient and healthy persons, the physiology parameters, which include the myocardial contractility, systemic vascular resistance (SVR), and vascular compliance, were studied. Through clinical data of HF patients, the computing method of the myocardial contractility was proposed; SVR as a function with respect to mean arterial pressure (MAP) was represented; and the vascular compliance was defined as a function with respect to MAP and cardiac output. Based on these parameters, a lumped parameter model of the cardiovascular system was established to reproduce the hemodynamic status of HF patients and verify the validity of the physiological mechanism. The simulation results demonstrate that the proportional error of mean flow, arterial pressure, and systolic blood pressure is 11.9%, 2.3%, and 4.7% compared with the clinical data, respectively. The proportional error of end-diastolic volume, end-systolic volume, and ejection fraction is 13.4%, 3%, and 3.9%, respectively. ASAIO Journal 2012; 58:223-231.Engineering, BiomedicalTransplantationSCI(E)EI0ARTICLE3223-2315