Aberrantly activated c-MET signaling occurs in several cancers, promoting the development of c-MET inhibitors. In this study, we found that eight of eight thyroid cancer cell lines (including six anaplastic thyroid cell lines) have prominent expression of c-MET protein. Fifty percent of the thyroid cancer cell lines (four of eight) were growth inhibited by two small molecule c-MET inhibitors (tivantinib and crizotinib) associated with apoptosis and G(2)-M cell-cycle arrest. However, crizotinib did not inhibit 50% proliferation of thyroid cancer cells (SW1736 and TL3) at a concentration at which the drug completely inhibited ligand-stimulated c-MET phosphorylation. However, tivantinib was less potent than crizotinib at inhibiting c-MET phosp...
Deregulated expression of the hepatocyte growth factor (HGF) receptor, c-Met, in cancer contributes ...
BACKGROUND: c-Met is a receptor tyrosine kinase (RTK) that is over-expressed in a variety of cancers...
The hepatocyte growth factor/c-MET signaling axis plays an important role in tumor cell proliferatio...
Aberrantly activated c-MET signaling occurs in several cancers, promoting the development of c-MET i...
The Met receptor tyrosine kinase is overexpressed and/or activated in variety of human malignancies....
IntroductionTyrosine kinase inhibitors (TKIs) targeted to MET are undergoing clinical trials in pati...
The receptor tyrosine kinase mesenchymal-epithelial transition factor (c-Met) plays a pivotal role i...
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate multiple...
BRAF (V600E) mutation is the most commonly detected genetic alteration in thyroid cancer. Unlike its...
Tumor growth and dissemination are often driven by stimulatory signaling pathways that can be target...
Nehad M Ayoub, Kamal M Al-Shami, Mohammad A Alqudah, Nizar M Mhaidat Department of Clinical Pharmac...
INTRODUCTION: C-Met plays important roles in treatment resistance, tumor invasion, and metastasis. I...
BACKGROUND/AIMS The hepatocyte growth factor/transmembrane tyrosine kinase receptor c-Met has bee...
Certain genetically defined cancers are dependent on a single overactive oncogene for their prolifer...
The c-Met pathway has been implicated in a variety of human cancers for its critical role in tumor g...
Deregulated expression of the hepatocyte growth factor (HGF) receptor, c-Met, in cancer contributes ...
BACKGROUND: c-Met is a receptor tyrosine kinase (RTK) that is over-expressed in a variety of cancers...
The hepatocyte growth factor/c-MET signaling axis plays an important role in tumor cell proliferatio...
Aberrantly activated c-MET signaling occurs in several cancers, promoting the development of c-MET i...
The Met receptor tyrosine kinase is overexpressed and/or activated in variety of human malignancies....
IntroductionTyrosine kinase inhibitors (TKIs) targeted to MET are undergoing clinical trials in pati...
The receptor tyrosine kinase mesenchymal-epithelial transition factor (c-Met) plays a pivotal role i...
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate multiple...
BRAF (V600E) mutation is the most commonly detected genetic alteration in thyroid cancer. Unlike its...
Tumor growth and dissemination are often driven by stimulatory signaling pathways that can be target...
Nehad M Ayoub, Kamal M Al-Shami, Mohammad A Alqudah, Nizar M Mhaidat Department of Clinical Pharmac...
INTRODUCTION: C-Met plays important roles in treatment resistance, tumor invasion, and metastasis. I...
BACKGROUND/AIMS The hepatocyte growth factor/transmembrane tyrosine kinase receptor c-Met has bee...
Certain genetically defined cancers are dependent on a single overactive oncogene for their prolifer...
The c-Met pathway has been implicated in a variety of human cancers for its critical role in tumor g...
Deregulated expression of the hepatocyte growth factor (HGF) receptor, c-Met, in cancer contributes ...
BACKGROUND: c-Met is a receptor tyrosine kinase (RTK) that is over-expressed in a variety of cancers...
The hepatocyte growth factor/c-MET signaling axis plays an important role in tumor cell proliferatio...