Prediction, synthesis and antigenicity of the antigenic peptides of 26 kDa glutathione S-transferase of Schistosoma japonicum (Sj26)

Six antigenic peptides of 26 kDa glutathione S-transferase of Schistosoma japonicum (Sj26) have been predicted according to their hydrophilicity, flexibility, accessibility, charge distribution and beta-turn in the secondary structure by the determination of its primary structure and synthesized by solid phase method. All of them showed antigenicity with anti-schistosoma japonicum immunoglobulin polyclonal antibody, anti-Sj-IgG PcAb by Dot-ELISA. Three of them showed good antigenicity. They would serve as candidates of synthetic anti-schistosomal vaccine.Chemistry, MultidisciplinarySCI(E)1ARTICLE127-281