An efficient algorithm for deciphering regulatory motifs

The identification of transcription factor binding sites (TFBS) by computational methods is very important in understanding the gene regulatory network. Although many methods have been developed to identifying TFBSs, they generally have relatively low accuracy, especially when the positions of the TFBS are dependent. Motivated by this challenge, an efficient algorithm, IBSS, is developed for the identification of TFBSs. Our results indicate that IBSS outperforms other approaches with a relatively high accuracy.BiophysicsMathematical & Computational BiologyCPCI-S(ISTP)