Preparation of Re-188-HEDP lyophilized kit for instant bone metastases therapy

Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of Re-188-HEDP. Re-188-HEDP showed high focile uptake in normal mice (> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000348411100009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Nuclear Science & TechnologyPhysics, NuclearSCI(E)0ARTICLEpekyz@163.com6null2